发布时间：2008.8
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Single user: USD:3000
DEPARTMENTAL (FIVE USERS)
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SITE
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GLOBAL SITE
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摘要
In 2007, the world market for bone metabolism disorder pharmaceuticals generated sales of over $10bn - how much of this market have you captured?
The majority of this market consists of the fast-expanding osteoporosis segment, a disease with high incidence and under-treatment at present. The bone metabolism market is competitive and progressive, facing generic competition amongst its top-selling drugs. Nevertheless, market growth will be driven by aging populations worldwide and the entry of novel therapies during the years ahead. In Osteoporosis & Bone Metabolism Disorders, 2008-2023, visiongain forecasts that the bone metabolism disorder market will increase - but by just how much? Order the report today to find out..
Worldwide, significant numbers of osteoporosis sufferers remain undiagnosed. Amongst those taking medication, patient compliance is poor. In addition, bone metabolism disease patients have significant unmet needs. All these factors provide additional opportunities for further growth in the market. During this growth period, there will be major changes in the nature and make-up of the bone metabolism disorder market. This will include the decline in bisphosphonate drugs and the emergence of novel therapies.
This visiongain report reviews the global bone metabolism disorder market in detail thorough comprehensive forecasting and other analysis, as well as interviews with experts in the field, including KOLs in industry. In particular, Osteoporosis & Bone Metabolism Disorders, 2008-2023 concentrates on the following essential aspects of the global osteoporosis and bone metabolism market:
* Financial forecasts covering the period 2008-2023, including leading brands, companies, country markets and therapeutic classes of drug
* Expert opinion from industry sources
* Identification of key drugs in a well-stocked bone metabolism disorder pipeline
* Key industrial players - established and emerging - in the bone metabolism market
* Geographical breakdown of the market, including sales forecasts for leading markets, including China and India
Why you should buy this report:
* To receive a comprehensive analysis of the prospects for the osteoporosis and bone metabolism industry from 2008-2023, including sales forecasts, major growth areas and most talked-about pipeline products
* To discover predicted revenues, growth rates and other key metrics for bone disorder drugs from 2008-2023, especially leading brands
* To determine the forces that influence the osteoporosis and bone metabolism market:
* Drivers and restraints on market
* Competition
* Strengths, weaknesses, opportunities and threats.
* To find out where the bone metabolism market is heading from 2008 onwards - both technologically and commercially
目录及图表
1 Executive Summary
2 Bone Metabolism Disorders: Causes, Diagnosis and Treatment
2.1 Bone is a Living Dynamic Tissue
2.1.1 Bone Structure
2.1.2 Bone Remodelling
2.1.3 Regulation of Bone Remodelling
2.1.3.1 Factors Affecting Bone Metabolism
2.1.3.2 Parathyroid Hormone (PTH)
2.1.3.3 Calcitonin
2.1.3.4 Vitamin D/Calcitriol
2.1.3.5 Other Hormones
2.1.3.6 Local Cell Signalling Factors
2.1.3.7 Physical Stress
2.1.4 Bone Growth and Remodelling During the Life-Cycle
2.2 Bone Metabolism Disorders
2.2.1 Osteoporosis
2.2.1.1 Osteoporosis Leads to Bone Fractures
2.2.1.2 Causes of Osteoporosis
2.2.1.3 Osteoporosis Risk Factors
2.2.1.4 Diagnosis of Osteoporosis
2.2.1.5 Osteoporosis Screening
2.2.1.6 Prevalence of Osteoporosis
2.2.1.7 Counting the Cost of Osteoporosis
2.2.2 Paget's Disease of Bone
2.2.2.1 Paget's Disease is a Chronic Skeletal Disorder
2.2.2.2 The Cause of Paget's Disease
2.2.2.3 Diagnosis of Paget's Disease
2.2.2.4 Prevalence of Paget's Disease
2.2.3 Bone Metastases
2.2.4 Primary Hyperparathyroidism
2.2.5 Secondary Hyperparathyroidism and Renal Osteodystrophy
2.3 Treatment of Bone Metabolism Disorders
2.3.1 Bisphosphonates
2.3.2 Vitamin D and K Analogues/Calcimimetics
2.3.3 Selective Oestrogen-Receptor Modulators (SERMs)
2.3.4 Parathyroid Hormones (PTH)
2.3.5 Calcitonins
2.3.6 Strontium Compounds
2.3.7 Hormone Replacement Therapy (HRT)
2.3.8 Calcium and Vitamin D Supplements
3 The World Bone Metabolism Disorder Market
3.1 The Bone Metabolism Market Will Grow 2023
3.2 Osteoporosis Dominates the Bone Metabolism Market
3.3 Bisphosphonates Lead the Bone Metabolism Market in 2007
3.4 Bisphosphonates Will Gradually Lose Market Share during 2008-2023
3.5 Key Industrial Players in the Bone Metabolism Market
3.6 Leading Brands in the Bone Metabolism Market
3.6.1 The Top 14 Bone Metabolism Drugs in 2007
3.6.2 Fosamax: A Fall from Top Position in 2008
3.6.3 Actonel/Optinate: Increasingly Impacted by Generic Competition
3.6.4 Zometa/Aclasta/Reclast (Zoledronate, Novartis): Further Growth Predicted
3.6.5 Bonviva/Boniva/Bondronat (Ibandronate, Roche/GSK): Strong Growth in Near Term
3.6.6 Bonalon/Teiroc (Alendronate, Teijin)
3.6.7 Benet (Risedronate, Takeda)
3.6.8 Bonefos (Clodronate, Bayer)
3.6.9 Generic Alendronate
3.6.10 Zemplar: New Formulations and Indications
3.6.11 Sensipar/Mimpara: Amgen's Calcimimetic
3.6.12 Alfarol (Alfacalcidol, Chugai)
3.6.13 Rocaltrol (Calcitriol, Roche)
3.6.14 Glakay (Vitamin K2, Eisai)
3.6.15 Evista: Only Slight Growth Predicted
3.6.16 Forteo/Forsteo: Strong Growth for a Bone Anabolic Agent
3.6.17 Preotact Will Not Challenge Forteo
3.6.18 Miacalcin/Miacalcic (Salmon Calcitonin, Novartis)
3.6.19 Elcitonin (Eel Calcitonin Derivative, Asahi Kasei)
3.6.20 Fortical (Salmon Calcitonin, Upsher-Smith)
3.6.21 Protelos (Strontium Ranelate, Servier)
3.6.22 Hormone Replacement Therapy (HRT)
3.6.23 The Leading Calcium and Vitamin D Supplements
4 SWOT Analysis of the Bone Metabolism Disorder Market
4.1 Analysis of the Market
4.2 Key Strengths of the Bone Metabolism Pharmaceutical Industry
4.3 Generic Competition is the Key Weakness Facing the Bone Metabolism Pharmaceutical Industry
4.4 Key Opportunities for the Bone Metabolism Market
4.5 Key Threats to the Bone Metabolism Market
4.5.1 Drug Side-Effect Publicity
4.5.2 Reimbursement of Bone Metabolism Drugs
5 Geographical Profile of the Bone Metabolism Market
5.1 North America Lead the Bone Metabolism Market in 2007
5.2 Leading Bone Metabolism Country Markets, 2007
5.3 Bone Metabolism Market Forecast for Leading Countries, 2008-2023
5.4 China and India Will Have Highest Growth in 2008-2023
6 The Bone Metabolism Disorder Pipeline
6.1 The Bone Metabolism Pipeline is Well-Stocked
6.2 More Convenient Formulations and Novel Therapeutics Fill the Bone Metabolism Pipeline
6.2.1 Pipeline Developments to Improve Formulations
6.2.2 Pipeline Bone Anabolic Agents
6.3 Monoclonal Antibodies and Cathepsin K Inhibitors will be the First Novel Therapeutics to Reach Market
6.4 Key Pipeline Products: Registration Stage
6.4.1 Fablyn (Lasofoxifene, Pfizer/Ligand)
6.4.2 Viviant (Bazedoxifene, Wyeth)
6.5 Key Pipeline Products: Phase III
6.5.1 Denosumab/AMG 162 (Amgen)
6.5.1.1 Denosumab is a Pipeline Product for Osteoporosis and Bone Metastases
6.5.1.2 Osteoporosis Clinical Trials
6.5.1.3 Bone Metastases Clinical Trials
6.5.1.4 Launch of Denosumab Expected in 2009-2010
6.5.2 Odanacatib (MK 0822, Merck & Co.)
6.5.3 Aprela (Conjugated Oestrogenic Substances/Bazedoxifene, Wyeth)
6.5.4 Arzoxifene (Eli Lilly)
6.5.5 Recalbon (ONO-5920/YM529, Minodronate, Ono/Astellas)
6.5.6 ED-71 (Eldecalcitol Chugai)
6.5.7 SMC021 (Salmon Calcitonin, Novartis/Nordic Bioscience/Unigene/Emisphere)
6.6 Key Pipeline Products: Phase II
6.6.1 ACE-011 (Acceleron Pharma)
6.6.2 BA058 (PTHrP Analogue, Radius Health/Ipsen)
6.6.3 Ronacaleret/751689 (GSK/NPS)
6.6.4 ONO-5334 (Ono)
6.6.5 rhPTH (Recombinant Human PTH, Green Cross)
6.6.6 BN003/CaPTHymone (Oral PTH, Bone Medical/Axcess)
6.6.7 ViaDerm-hPTH (PTH, TransPharma/Eli Lilly)
6.6.8 NBS-101 (Strontium Malonate, Osteologix)
6.6.9 Capsitonin (Oral Calcitonin, Bone Medical)
7 Conclusions
Appendix A
About visiongain
Appendix B
Visiongain Report Evaluation Form
List of Tables
Table 2.1 Hormones Involved in Bone Metabolism
Table 2.2 Worldwide Prevalence of Osteoporosis
Table 2.3 Bone Metabolism Disease Therapies
Table 3.1 World Bone Metabolism Disorder Pharmaceutical Sales ($m) 2007-2023
Table 3.2 World Bone Metabolism Market Share by Disorder, 2007
Table 3.3 World Bone Metabolism Market Share by Drug Class, 2007
Table 3.4 World Bone Metabolism Disorder Sales ($m) by Drug Class, 2007-2023
Table 3.5 World Bone Metabolism Disorder Market Share by Manufacturer, 2007
Table 3.6 Leading Bone Metabolism Disorder Brands, 2007
Table 3.7 Leading Bone Metabolism Disorder Brand Sales ($m), 2007- 2023
Table 3.8 Key Generic Alendronate Manufacturers, 2007
Table 3.9 Largest-Selling HRT Products, 2007
Table 4.1 SWOT Chart for Bone Metabolism Disorder Market
Table 4.2 Selected Expected Patent-Expiries in the Bone Metabolism Market 2008-2023
Table 4.3 Premarin Sales Revenue 2002-2004
Table 5.1 World Bone Metabolism Disorder Market Share by Geographical Area, 2007
Table 5.2 Top Bone Metabolism Country Markets, 2007
Table 5.3 Leading Bone Metabolism Country Markets, 2007-2023
Table 5.4 Population Aged 65 or Over: US, Japan China and India, 2007-2023
Table 6.1 The Bone Metabolism Disorder Pipeline
Table 7.1 Leading Bone Metabolism Country Markets 2007 and 2023
List of Figures
Figure 2.1 Appearance of Healthy Bone
Figure 2.2 Bone Affected by Osteoporosis
Figure 2.3 Bones Commonly Affected by Paget's Disease
Figure 3.1 World Bone Metabolism Disorder Pharmaceutical Sales ($m) 2007-2023
Figure 3.2 World Bone Metabolism Market Share by Disorder, 2007
Figure 3.3 World Bone Metabolism Disorder Market Share by Drug Class, 2007
Figure 3.4 World Bone Metabolism Disorder Sales ($m) by Drug Class, 2007-2023
Figure 3.5 World Bone Metabolism Disorder Market Share by Drug Class, 2013
Figure 3.6 World Bone Metabolism Disorder Market Share by Drug Class, 2018
Figure 3.7 World Bone Metabolism Disorder Market Share by Drug Class, 2023
Figure 3.8 World Bone Metabolism Disorder Market Share by Manufacturer, 2007
Figure 3.9 Leading Bone Metabolism Disorder Brands, 2007
Figure 3.10 Leading Bone Metabolism Brand Sales ($m) (Bisphosphonates), 2007-2023
Figure 3.11 Leading Bone Metabolism Brand Sales (Non-Bisphosphonates), 2007-2023
Figure 3.12 Fosamax/Fosamax Plus D Worldwide Sales Forecast ($m), 2007-2023
Figure 3.13 Actonel/Optinate Worldwide Sales Forecast ($m), 2007-2023
Figure 3.14 Zometa/Aclasta/Reclast Worldwide Sales Forecast ($m), 2007-2023
Figure 3.15 Bonviva/Boniva/Bondronat Worldwide Sales Forecast ($m), 2007-2023
Figure 3.16 Zemplar Worldwide Sales Forecast ($m), 2007-2023
Figure 3.17 Sensipar/Mimpara Worldwide Sales Forecast ($m), 2007- 2023
Figure 3.18 Evista Worldwide Sales Forecast ($m), 2007-2023
Figure 3.19 Forteo/Forsteo Worldwide Sales Forecast ($m), 2007-2023
Figure 3.20 Miacalcin/Miacalcic Worldwide Sales Forecast ($m), 2007- 2023
Figure 3.21 Protelos Worldwide Sales Forecast ($m), 2007-2023
Figure 5.1 World Bone Metabolism Disorder Market Share by Geographical Area, 2007
Figure 5.2 World Bone Metabolism Disorder Market Share by Leading Countries, 2007
Figure 5.3 Leading Bone Metabolism Country Markets, 2007-2023: Higher Group
Figure 5.4 Leading Bone Metabolism Country Markets, 2007-2023: Lower Group
Figure 5.5 World Bone Metabolism Disorder Market Share by Leading Countries, 2013
Figure 5.6 World Bone Metabolism Disorder Market Share by Leading Countries, 2018
Figure 5.7 World Bone Metabolism Disorder Market Share by Leading Countries, 2023
Figure 7.1 Bone Metabolism Disorder Market, 2007-2023
Companies Listed
Abbott Laboratories
Abiogen
Acceleron Pharma
American College of Physicians
Amgen
Asahi Kasei
Astellas
Axcess
Banyu
Barr
Bayer
Bone Medical
British Geriatrics Society
British Orthopaedic Association
Celgene
Chugai (part of Roche Group)
Daiichi Sankyo
Dr.Reddy's
Eisai
Eli Lilly
Emisphere Technologies
Esteve
European Medicines Agency (EMEA)
Food and Drug Administration (FDA)
Green Cross
GlaxoSmithKline (GSK)
International Osteoporosis Foundation
Ipsen
Kirin Brewery
Leo Pharma
Ligand
Merck & Co.
Nordic Bioscience
Novartis
Novo Nordisk
NPS
Nycomed
Ono
Osteologix
Preventive Services Task Force (USPSTF)
Proctor & Gamble
Radius Health
Ratiopharm
Roche
Sandoz (Novartis)
Sanofi-Aventis
Servier
Shire
Sigma (Australia)
Stada
Taisho
Takeda
Teijin
Teva
TransPharma
Unigene
Upsher-Smith
Watson
World Health Organisation (WHO)
Wyeth