发布时间：2008.5

摘要

This report analyzes the worldwide markets for Botulinum Toxin in Millions of US$. The end-use segments analyzed are Cosmetic Applications, and Therapeutic Applications. The report provides separate comprehensive analytics for the USA, Japan, Europe, and Rest of World. Annual forecasts are provided for each region for the period of 2000 through 2015. The report profiles 15 companies including many key and niche players worldwide such as Allergan, Inc., Ipsen Group, Metabiologics, Inc., Merz Pharmaceuticals GmbH, Mentor Corporation, and Solstice Neurosciences, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

目录及图表

TABLE OF CONTENTS   
 
  BOTULINUM TOXIN (Complete Report) Pages : 118   | $3950 
 
 I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 3 $100
 
     Study Reliability and Reporting Limitations.....I-1    
 
     Disclaimers.....I-2
Data Interpretation & Reporting Level.....I-2    
 
     Product Definitions and Scope of Study.....I-3
Cosmetic Applications.....I-3
Therapeutic Applications.....I-3    
 
 II. EXECUTIVE SUMMARY 47 $2250
 
    1. Industry Overview.....II-1 4  $400  
 
      態right?Outlook Forecast for Botulinum Toxin.....II-1
Growth Drivers for Botulinum Toxin.....II-1
Market Dynamics.....II-1
Combination Therapy Supports Market Growth.....II-1 1 $100
 
      Botulinum Toxin and Soft Tissue Filling Agents.....II-2
Botulinum Toxin Injections and Laser Resurfacing.....II-2
Botulinum Toxin and Phenol.....II-2
Technological Innovations Drive Botulinum Market.....II-2 1 $100
 
      Changing Consumer Belief.....II-3
Under-Treated Diseases Boost Demand for Off- Label Products.....II-3
Burgeoning Consumer Awareness.....II-3
慒eeling?to Look Good - Driving Aesthetic Market.....II-3
Expansion of Financing Services to Propel Growth.....II-3
Adverse Effects Impedes Market Growth.....II-3 1 $100
 
      High Cost ?A Major Market Restraint.....II-4
Concern over Long-Term Side Effects.....II-4 1 $100
 
    2. Competitive Landscape.....II-5 5  $900  
 
      Allergan Dominates Global Botulinum Toxin Market.....II-5
Table 1: Revenues of Allergan, Inc (2001-2005): Net Sales of Botox?Neuromodulator(In US$ Million) (includes corresponding Graph/Chart).....II-5 1 $300
 
      Botox Dominance Remains Stable in the Global Market.....II-6
Clinical Trails in Progress for Botox.....II-6
Ipsen ?Major Player in Botulinum Toxin Market.....II-6
Table 2: Revenues of Ipsen Group (2004 & 2005): Net Sales of Dysport?(In € Million).....II-6 1 $300
 
      Clinical Trails in Progress for Dysport.....II-7
Solstice - Only Global Manufacturer of Type B Botulinum Toxin.....II-7
Table 3: Leading Players in Global Botulinum Toxin (Therapeutic) Market (2005): Percentage Breakdown by Revenues for Allergan (Botox?, Solstice (Myobloc?, Ipsen and (Dysport? (includes corresponding Graph/Chart).....II-7

Table 4: Leading Players in Global Botulinum Toxin (Cosmetic) Market (2005): Percentage Breakdown by Revenues for Allergan (Botox?, Ipsen (Dysport?Reloxin?, and Others (includes corresponding Graph/Chart).....II-7 1 $300
 
      Worldwide Botulinum Toxin Market (2005): Competitors Profile of the Top 2 Companies.....II-8
Comparison of Allergan抯 Botox?and Ipsen抯 Reloxin?....II-8  1 $100
 
      Table 5: Worldwide Botulinum Toxin Market (2005 & 2006): Percentage Breakup by Key Products ?Botox? Dysport? Myobloc? and Others?(includes corresponding Graph/Chart).....II-9 1 $300
 
    3. Product Overview.....II-10 25  $1200  
 
      Botulinum Toxin ?An Introduction.....II-10 1 $100
 
      Chemical Overview.....II-11
Mechanism of Botulinum Toxin.....II-11
Side Effects.....II-11 1 $100
 
      Immunogenicity Effects Response to Botulinum Therapy.....II-12
A Peek into the History and Development.....II-12 1 $100
 
      Botulinum Toxin ?A Classification.....II-13
Botulinum Toxin Type A.....II-13
Botox?....II-13 1 $100
 
      Historical Timeline of Botox: 1885-2002.....II-14 1 $100
 
      Botox Approvals and Indications in Select Global Regions.....II-15
Dysport?....II-15
Xeomin?....II-15
Botulinum Toxin Type B.....II-15 1 $100
 
      Myobloc?....II-16
Key Products in Botulinum Toxin Type A, Type B.....II-16 1 $100
 
      Competitive Overview of Botox?- Cosmetic Purpose (Smoothing of Facial
  Wrinkles).....II-17
Other Types.....II-17
Applications of Botulinum Toxin.....II-17
Botulinum ?Toxin or Treatment?.....II-17 1 $100
 
      Therapeutic Applications of Botulinum Toxin.....II-18
Botulinum Toxin for Movement Disorders.....II-18
Botulinum Toxin Cures Dystonia.....II-18 1 $100
 
      Botulinum is Beneficial for Cervical Dystonia.....II-19
Botulinum Toxin Cures Laryngeal Dystonia.....II-19
Ease from Writer抯 Cramp.....II-19 1 $100
 
      Botulinum ?Useful To Treat Oromandibular Dystonia.....II-20
Tics.....II-20
Tremors.....II-20
Parkinson's Disease.....II-20
Botulinum Toxin Treats Hemifacial Spasm.....II-20 1 $100
 
      Is Botulinum Toxin an Answer to Blepharospasm?.....II-21
Tantalizing Effect in Strabismus.....II-21
Childhood Strabismus.....II-21 1 $100
 
      Botulinum Toxin Helps Spasticity Cure Better.....II-22
Stroke.....II-22
Traumatic Brain Injury.....II-22
Cerebral Palsy.....II-22 1 $100
 
      Multiple Sclerosis.....II-23
Botulinum Toxin Soothes Pain.....II-23
Botulinum Heals Hypertonic Disorders.....II-23 1 $100
 
      Cosmetic Applications of Botulinum Toxin.....II-24
Botulinum Toxin Irons Out Facial Wrinkles.....II-24 1 $100
 
      Botulinum Lessens Facial Scarring.....II-25
Botulinum Toxin (Botox) Users Becoming Addictive.....II-25
Key Cosmetic Indications for Botulinum Toxin.....II-25 1 $100
 
      Additional Applications.....II-26
Positive Response of Rigid Spine Syndrome to Botulinum Toxin.....II-26
Botulinum Toxin Effective in Bladder Dysfunctions.....II-26 1 $100
 
      Botox Provides Respite from Tinnitus.....II-27
Botulinum Toxin for Anal Fissure.....II-27
Can Botox Prevent Baldness?.....II-27
Refractory Vaginismus and Botulinum.....II-27 1 $100
 
      Botulinum Toxin Helps to Cure Dysphagia.....II-28
Encouraging Effects of Botox in Migraine.....II-28
Botulinum Eases Severe Facial Pain.....II-28
Botulinum Provides Relief from Pelvic Floor Pain.....II-28 1 $100
 
      Botox Can Treat Children with Non-Neurogenic, Neurogenic Bladder.....II-29
Botulinum Toxin Finds Application in Cancer Treatment.....II-29
Botox Can Reduce Pain, Itching and Hand Eczema.....II-29
Botulinum Reduces Plantar Fasciitis Pain.....II-29
Botox Helps to Treat Carpal Tunnel Syndrome.....II-29 1 $100
 
      Other Indications for Botulinum Toxin.....II-30
Terrorist and Military Exploitation of Botulinum Toxin.....II-30
Botulism ?Infection from Botulinum.....II-30 1 $100
 
      Types of Botulism.....II-31
Classical or Food Borne Botulism.....II-31
Home Canning ?Culprit Behind Botulism.....II-31 1 $100
 
      Wound Botulism.....II-32
Infant Botulism.....II-32
Botulism Outbreak in Animals.....II-32 1 $100
 
      Safety Precautions.....II-33
Medicinal Investigations.....II-33 1 $100
 
      Vaccine for Botulinum Toxin.....II-34
Technological Development.....II-34
US Inventor Develops New Fermentation Process.....II-34 1 $100
 
    4. Recent Industry Activity.....II-35 5  $500  
 
      Allergan and Clinique Form Strategic Collaboration.....II-35
Ipsen and Medicis File BLA for Reloxin?....II-35
Medicis Plans Investment in Revance.....II-35
Galderma Receives Distribution Rights for Dysport (R).....II-35
Allergan to Acquire Espirit Pharma.....II-35 1 $100
 
      Allergan Launches "Project: Sweat Free".....II-36
Solstice Neurosciences Inks Commercialization Agreement.....II-36
Ipsen Partners with Galderma.....II-36
Allergan Rolls Out New Division with Acquisition of Inamed.....II-36
FTC Mandates Allergan Divest Rights to Reloxin.....II-36
Medicis Inks Agreement with Ipsen.....II-36 1 $100
 
      Solstice Neurosciences Inks Licensing Agreement with DreamPharma.....II-37
Botox Enters India Market.....II-37
Mentor Begins Phase-I Clinical Trial on Botulinum Toxin .....II-37
Allergan Inks Agreement with GlaxoSmithKline.....II-37 1 $100
 
      DOR BioPharma Inks Agreement with Dowpharma.....II-38
Merz Pharma Receives Approval for Botulinum Toxin Type A.....II-38
Mentor Initiates Phase-I Clinical Trial.....II-38
Mentor Establishes New Production Facility.....II-38
DOR BioPharma and Thomas Jefferson University Teams-Up with US Army.....II-38 1 $100
 
      Mentor Inks Licensing Agreement with WARF.....II-39
Solstice Acquires World Rights for Myobloc.....II-39
Inamed Rolls Out Reloxin Brand.....II-39 1 $100
 
    5. Focus on Select Key Players.....II-40 2  $200  
 
      Allergan, Inc (USA).....II-40
Ipsen Group (France).....II-40
Metabiologics Inc, (USA).....II-40 1 $100
 
      Merz Pharmaceuticals GmbH (Germany).....II-41
Mentor Corporation (USA).....II-41
Solstice Neurosciences, Inc. (USA).....II-41 1 $100
 
    6. Global Market Perspective.....II-42     
 
      Table 6: World Recent Past, Current & Future Analysis for Botulinum Toxin by Geographic Region ?US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart).....II-42

Table 7: World Long-term Projections for Botulinum Toxin by Geographic Region ?US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart).....II-42 1 $300
 
      Table 8: World 10-Year Perspective for Botulinum Toxin by Geographic Region ?Percentage Breakdown of Dollar Sales for US and Rest of World for the Years 2003, 2008 & 2012.....II-43 1 $300
 
      Table 9: World Recent Past, Current & Future Analysis for Botulinum Toxin in Cosmetic Applications by Geographic Region ?US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart).....II-44

Table 10: World Long-term Projections for Botulinum Toxin in Cosmetic Applications by Geographic Region ?US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart).....II-44 1 $300
 
      Table 11: World 10-Year Perspective for Botulinum Toxin in Cosmetic Applications by Geographic Region ?Percentage Breakdown of Dollar Sales for US and Rest of World for the Years 2003, 2008 & 2012.....II-45 1 $300
 
      Table 12: World Recent Past, Current & Future Analysis for Botulinum Toxin in Therapeutic Applications by Geographic Region ?US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart).....II-46

Table 13: World Long-term Projections for Botulinum Toxin in Therapeutic Applications by Geographic Region ?US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart).....II-46 1 $300
 
      Table 14: World 10-Year Perspective for Botulinum Toxin in Therapeutic Applications by Geographic Region ?Percentage Breakdown of Dollar Sales for US and Rest of World for the Years 2003, 2008 & 2012.....II-47 1 $300
 
 III. MARKET 24 $1950
 
    1. The United States.....III-1 17  $1175  
 
      A. Market Analysis.....III-1
Botulinum Toxin Market to Grow at a Healthy Rate.....III-1
Botox Leads the US Botulinum Toxin Market.....III-1
Botox Growth - Largely Supported by FDA Approval for Cosmetic Use.....III-1 1 $85
 
      Botox Approvals and Indications in the US.....III-2
Market Dynamics.....III-2
Booming Non-Surgical Treatments.....III-2
Aging Baby Boomers Drive Aesthetic Business.....III-2
Increasing Physician Base Impels Botulinum Market.....III-2 1 $85
 
      Direct-to-Consumer Advertising Drive Cosmetic Botulinum Toxin.....III-3
Increasing Off-label Use of Botulinum Toxin.....III-3
Medical Spas ?Growing in Number.....III-3
Heightened Competition Limits Growth.....III-3 1 $85
 
      Arduous Regulations Deter Product Progress.....III-4
Botulism Poisoning ?A Major Concern.....III-4
Botox Injection ?Popular Non-Invasive Cosmetic Procedure.....III-4  1 $85
 
      Table 15: Number of Botox Injections (2000-2005) (includes corresponding Graph/Chart).....III-5

Table 16: Botox Injections by Gender (2004).....III-5

Table 17: Botox Injections by Age Group (2004) (includes corresponding Graph/Chart).....III-5 1 $150
 
      Botox Attracts American Men.....III-6
Table 18: Non-Invasive Cosmetic Procedures in the US (2005): Percentage of Patients Treated by All US-Based AACS Members Practices (includes corresponding Graph/Chart).....III-6

Table 19: Cosmetic Procedures (Surgical/Non-Surgical) in the US (2005): Percentage of Patients Treated by All US-Based AACS Members Practices.....III-6 1 $150
 
      Factors to be Considered Prior to Cosmetic Botox Treatment.....III-7
Botox for Spasticity ?Improved Quality of Life.....III-7
Coding and Reimbursement.....III-7 1 $85
 
      US Cosmetic Market ?Statistical Data.....III-8
Table 20: Cosmetic Market in the US (2004 & 2005): Leading Surgical Procedures (includes corresponding Graph/Chart).....III-8 1 $150
 
      Table 21: Cosmetic Market in the US (2004 & 2005): Leading Non-Surgical Procedures (includes corresponding Graph/Chart).....III-9

Table 22: Number of Cosmetic Procedures in the US (2005): Percentage Breakdown by Gender.....III-9

Table 23: Number of Cosmetic Procedures in the US (2005): Percentage Breakdown by Age Group (includes corresponding Graph/Chart).....III-9 1 $150
 
      Table 24: Number of Cosmetic Procedures in the US (2005): Percentage Breakdown by Facility (includes corresponding Graph/Chart).....III-10

Table 25: Cosmetic Market in the US (2004): Percentage Breakdown by Procedure Type.....III-10
Technological Development.....III-10
Strategic Corporate Developments.....III-10 4 $600
 
      Key Players.....III-14 2 $170
 
      B. Market Analytics.....III-16
Table 26: US Recent Past, Current & Future Analysis for Botulinum Toxin by Application ?Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart).....III-16

Table 27: US Long-term Projections for Botulinum Toxin by Application ?Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart).....III-16 1 $150
 
      Table 28: US 10-Year Perspective for Botulinum Toxin ?Percentage Breakdown of Dollar Sales for Cosmetic Applications and Therapeutic Applications for the Years 2003, 2008 & 2012.....III-17 1 $150
 
    2. Rest of World.....III-18 7  $725  
 
      A. Market Analysis.....III-18
Current and Future Analysis.....III-18
Europe.....III-18
Botox Demand Increases with Zeal For Beauty.....III-18
Botox Approvals and Indications in Select European Countries.....III-18 1 $85
 
      Botox to Support Radiation Treatments.....III-19
Asia.....III-19
India ?An Emerging Market for Botox.....III-19
Korea ?Fast Catching Up the Trend.....III-19
Australia ?A Well Supported Market.....III-19 1 $85
 
      Botox Approvals and Indications in Select Asian Countries.....III-20
Botox Approvals and Indications in Select Latin American Regions.....III-20 1 $85
 
      Botox Approvals and Indications in Other Select Global Regions.....III-21
Strategic Corporate Developments.....III-21 1 $85
 
      Key Players.....III-22 1 $85
 
      B. Market Analytics.....III-23
Table 29: Rest of World Recent Past, Current & Future Analysis for Botulinum Toxin by Application ?Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart).....III-23 1 $150
 
      Table 30: Rest of World Long-term Projections for Botulinum Toxin by Application ?Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart).....III-24

Table 31: Rest of World 10-Year Perspective for Botulinum Toxin ?Percentage Breakdown of Dollar Sales for Cosmetic Applications and Therapeutic Applications for the Years 2003, 2008 & 2012.....III-24 1 $150
 
 IV. COMPETITIVE LANDSCAPE  39 $995
 
     Total Companies Profiled: 15 (including Divisions/Subsidiaries - 17)
--------------------------------------------------------------------------------Region/Country                 Players
--------------------------------------------------------------------------------
The United States                  7
Japan                              1
Europe                             4
     France                        1
     Germany                       2
     The United Kingdom            1
Asia-Pacific (Excluding Japan)     5