发布时间：2008.5
摘要
This report analyzes the worldwide markets for Proteomics in Millions of US$. The major Product segments analyzed are Expression Proteomics, Functional Proteomics, and Structural Proteomics.The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, and Rest of World. Annual forecasts are provided for each region for the period of 2003 through 2015. The report profiles 170 companies including many key and niche players worldwide such as Agilent Technologies, Inc., Applied Biosystems, Bio-Rad Laboratories, Inc., Dionex Corporation, GE Healthcare, Biacore Life Sciences, Invitrogen Corporation, PerkinElmer, Inc., Proteome Systems Ltd., Shimadzu Biotech, and Thermo Fisher Scientific. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
目录及图表
TABLE OF CONTENTS
PROTEOMICS (Complete Report) Pages : 681 | $3950
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 4 $100
Study Reliability and Reporting Limitations.....I-1
Disclaimers.....I-2
Data Interpretation & Reporting Level.....I-2
Quantitative Techniques & Analytics.....I-2
Product Definitions and Scope of Study.....I-3
Expression Proteomics.....I-3
Functional Proteomics.....I-3
Structural Proteomics.....I-4
II. EXECUTIVE SUMMARY 66 $2250
1. Global Market Overview.....II-1 5 $500
Current Spotlight.....II-1
Genesis of Proteomics.....II-1 1 $100
Tales From Times Gone By.....II-2
Proteomics: A Critical Drug Discovery Tool.....II-2 1 $100
Factors Influencing the Market.....II-3
Market Drivers.....II-3 1 $100
Factors Limiting Market Growth.....II-4
Major Challenges.....II-4
Proteomics Sample Preparation Market.....II-4
Protein Chemistry and its Complexities.....II-4
Integration of Data & Equipment.....II-4
Data Validation - A Burning Issue.....II-4 1 $100
Standardization & Consistency- A Prime Concern.....II-5 1 $100
2. Industry Competition.....II-6 3 $300
Industry Participants.....II-6
Proteomics Market Worldwide: Competitive Landscape.....II-6
Proteomics Supplier Market.....II-6 1 $100
Challenges Ahead.....II-7
Designing a Novel Business Model.....II-7 2 $200
3. Product and Technology Overview.....II-9 7 $700
Proteins, Proteome and Proteomics !!!- What are They?.....II-9
Proteomics ?An Introduction.....II-9 1 $100
Components of Proteomics.....II-10
Expression Proteomics.....II-10
Functional Proteomics.....II-10
Cell-map Proteomics.....II-10
Structural Proteomics.....II-10
Technologies and Proteomics.....II-10 1 $100
Proteomics and Genomics.....II-11
Proteomics and Genomics: A Comparison.....II-11
Protein Production Pathway: From Gene Expression to Functional Protein with
Controls.....II-11 1 $100
From Genomics to Proteomics.....II-12
Functional Genomics and Proteomics.....II-12 1 $100
Push From Genomic Information.....II-13
Standard Proteomics Approach.....II-13
Sample Preparation- Step I.....II-13 1 $100
Protein Separation-Step II.....II-14
Protein Visualization.....II-14
Protein Expression Analysis-Step III.....II-14 1 $100
Protein Identification 朣tep IV.....II-15
Data Storage and Processing-Step V.....II-15 1 $100
4. Overview of Proteomics Technologies.....II-16 12 $800
A Snapshot of Various Proteomics Tools.....II-16
An Insight into Various Proteomics Technologies and their Application Areas.....II-16
Protein Separation.....II-16 1 $100
Table 1: Worldwide Protein Separation Market (2003-2008P): Market Share of Leading Players- Applied Biosystems, Waters Corp., Amersham Biosciences, Agilent Technologies Inc., Bio-Rad/ Micromass, Thermo Electron, and Others (Includes corresponding Graph/Chart).....II-17
2-Dimensional Gel Electrophoresis (2DGE).....II-17 2 $200
Protein Characterization.....II-19
Analysis of Protein Through Mass Spectrometry.....II-19
MS and Proteins.....II-19 2 $200
Y2H, Yeast 2-Hybrid System.....II-21 1 $100
Protein Microarrays.....II-22
Chip Technology.....II-22 1 $100
Microfluidic Applications.....II-23
Role of Bioinformatics in Proteomics.....II-23
Bioinformatics Applications and Tools in Proteomics.....II-23 2 $200
Emerging Proteomics Technologies.....II-25
MudPIT.....II-25
ICAT .....II-25 1 $100
Phage Display Technique.....II-26
Advanced Proteomics Technologies: Structural Analysis Tools.....II-26
X-ray Crystallography.....II-26
Nuclear Magnetic Resonance (NMR).....II-26 1 $100
In silico Modelling.....II-27
Physicochemical Factors Constraining Metabolic Functions.....II-27 1 $100
5. End-Use Application Areas.....II-28 4 $400
End-Use Application Areas.....II-28 1 $100
Proteomics in Drug and Diagnostic Discovery.....II-29
Proteomics and Drug Discovery.....II-29 1 $100
Proteomic Approaches Gaining Prominence in Cancer Drug Discovery.....II-30 1 $100
Leading Companies in Proteomics-Based Drug Discovery.....II-31
Future of Proteomics in Drug Discovery.....II-31 1 $100
6. New Product Solutions/Developments.....II-32 13 $800
Bruker Daltonics Introduces Advanced ETD II Module.....II-32
Applied Biosystems Expands its iTRAQ?Line of Labeling Reagents.....II-32
PerkinElmer Expands Its Imaging Technologies and Protein Analysis Product
Portfolio.....II-32 1 $100
Sigma-Aldrich Introduces new Proteomics Dynamic Range Standard.....II-33
Thermo Fisher Scientific Expands Mass Spectrometry Portfolio .....II-33
Bruker Daltonics Launches New Versions of Compass? and ProteinScape?
Softwares.....II-33 1 $100
Applied Biosystems and Sciex Roll Out New Proteomic Tools.....II-34
Bruker Daltonics Rolls Out New Compass?1.2 Software.....II-34
Bruker Daltonics Unveils New Mass Spectrometer, apex?ultra FTMS.....II-34
Thermo Fisher Unveils the Latest LTQ XL mass spectrometer.....II-34 1 $100
Genedata Introduces Genedata Expressionist?Pro 3.0.....II-35
Biozentrum to Employ GeneBio抯 Phenyx as Primary Search Engine.....II-35
Shimadzu Biotech Unveils AXIMA-TOF2.....II-35 1 $100
Waters Corporation Unveils Latest Columns for Peptide Analysis and Isolation.....II-36
Applied Biosystems and MDS Sciex Unveil QSTAR? Elite LC/MS/MS System.....II-36
Waters Corporation to Roll out Updated ProteinLynx Global SERVER?Version.....II-36 1 $100
Syngene Unveils the Latest Integrated Proteomics Products.....II-37
Sigma Unveils the Latest ProteoPrep 20 Plasma Immunodepletion Kit.....II-37
Sigma-Aldrich Introduces First Commercial Proteomics Standard.....II-37 1 $100
Bruker Daltonics and Serva Electrophoresis Unveil ICPL Triplex kit.....II-38
Agilent Unveils 3100 OFFGEL Fractionator.....II-38
Agilent Technologies Unveils Multiple Affinity Removal System 7.....II-38 1 $100
Bio-Rad Unveils Proteon XPR36 Protein Interaction Array System.....II-39
Sigma-Aldrich Adds Panorama Human Kinase v1 Array to Extend Panorama Protein Array
Line.....II-39
PerkinElmer Expands Proteomic Research Tools Offering.....II-39
Waters Launches Advanced Version of Proteomics Research Software.....II-39 1 $100
Lumera to Develop New Protein Biochip in Collaboration with HMS.....II-40
Agilent Launches Ion Trap Mass Spectrometer, LC/MSD Trap XCT Ultra .....II-40
Bruker Launches Novel Mass Spectrometer System, HCTultra .....II-40
Bruker Launches Novel Post-Translational Protein Technique.....II-40 1 $100
Kinexus Launches New Functional Proteomic Database.....II-41
Applied Biosystems Launches Series of Liquid Chromatography Systems.....II-41
Pall Introduces Three Novel Protein Purification Kits.....II-41
Ciphergen Launches Nex-Gen ProteinChip System, Series 4000.....II-41
Ciphergen Introduces Protein Software in Collaboration with Salford.....II-41 1 $100
Bruker Launches New Proteomics RIMS.....II-42
Invitrogen Launches High-Density Protein Microarray.....II-42
Amersham Biosciences Introduces Improved 2-D Software .....II-42
Proteome Introduces Latest Version of Proteomic Software Solutions .....II-42
Proteome Systems Introduces Intelligent Electrophoresis Solutions.....II-42 1 $100
Applied Biosystems Develops 4700 System.....II-43
Biacore Launches Functional Proteomics System.....II-43
Biacore Launches Software and Sensor Chips.....II-43
Biacore Launches Procel?....II-43
Agilent Introduces Dual Loop Autosampler for HPLC Purification.....II-43
Agilent Introduces New Methods for RNAi.....II-43 1 $100
Agilent Introduces Human 1B Oligo Microarray Kit.....II-44
Agilent Introduces New Seperation System.....II-44
Agilent Introduces Nano-flow LC System.....II-44
Ciphergen Launches IDM Platform.....II-44
Dionex Releases Monolithic Capillary Columns.....II-44
Beckman Enhances the Product Line of ProteomeLab.....II-44 1 $100
7. Recent Industry Activity.....II-45 12 $800
Sigma-Aldrich Enters an Exclusive Alliance with Atlas Antibodies to Distribute New
Prestige Antibodies?....II-45
Nonlinear Dynamics Inks Distribution Agreement with UVP, LLC.....II-45
Plexera Enters into an Access Agreement with Auguron for NAPPA.....II-45
NextGen and Paragon Bioservices Enter into a Commercial Partnership Agreement.....II-45 1 $100
Digilab Acquires Genomic Solutions and MAIA Scientific from Harvard Bioscience.....II-46
Power3 Ropes in FAH to Distribute its BC-SeraPro? in the Middle East.....II-46
Thallion Sells Majority Stake to US-based Private Equity Firm, Great Point
Partners.....II-46
Ecopia and Caprion Merge to Form Thallion Pharmaceuticals.....II-46 1 $100
BG Medicine and Applied Biosystems Collaborate for Biomarker Discovery and
Development.....II-47
Bio-Rad Acquires Ciphergen抯 Proteomics Instrument Business.....II-47
BioMachines Establishes New Proteomics Services Unit.....II-47
GE Acquires Biacore.....II-47 1 $100
Fuji Film Acquires Minority Stake in Perseus.....II-48
Cenix BioScience, Applied Biosystems, and Biotec of the Technische Universit鋞 Dresden
Collaborate.....II-48
GeneBio and Goodlett Enter into Collaboration.....II-48 1 $100
Genetix Group to Acquire Applied Imaging.....II-49
Massively Parallel Technologies Signs a Deal with University of Colorado.....II-49
Genospectra Plans Merger with Panomics.....II-49 1 $100
PerkinElmer Announces Acquisition of Proteomics Labeling Technology .....II-50
ActivX Biosciences Extends Alliance with Pfizer .....II-50
Invitrogen Acquires Zymed .....II-50
FALCO Signs a Collaborative Agreement with PPD.....II-50
Invitrogen Acquires BioSource International .....II-50
Agilix and Protana Enters into a Licensing Agreement .....II-50 1 $100
Invitrogen Pacts Marketing Agreement with Applied Biosystems .....II-51
Waters Corp. Pacts a Technical Collaboration with Matrix.....II-51
Kyorin Acquires ActivX Biosciences .....II-51
Bruker Signs Marketing Agreement with Serva Electrophoresis .....II-51
PerkinElmer Enters into a Marketing Agreement with NLD .....II-51 1 $100
Pepscan Collaborates with Cytos Biotechnology ......II-52
BD Acquires Protein Separation Technology of FFE Weber .....II-52
Invitrogen Acquires Caltag Laboratories .....II-52
Qiagen Acquires Major Assets of LumiCyte.....II-52
LifeSpan BioSciences Inks Long-Term Agreement with Pfizer.....II-52 1 $100
Dana-Farber Cancer Institute To Establish Proteomics Research Center.....II-53
Bruker, University of Goettingen and PANATecs Signs an Development Agreement.....II-53
NextGen Sciences Partners with Protagen.....II-53
GeneBio Collaborates with Genedata .....II-53
Sage-N Research to Establish R&D Center in China.....II-53 1 $100
Sage-N Research Integrates Sorcerer?Systems with TPP analysis Platform of ISB.....II-54
Agilent Introduces Whole Human Genome Microarray.....II-54
Invitrogen Acquires Protometrix .....II-54
Nanogen Acquires SXP .....II-54
BioCrossroads Establishes INCAPS, Protein Center of Excellence.....II-54 1 $100
Ciphergen Acquires Remaining Stake in Ciphergen Biosystems K.K......II-55
Shimadzu Inks OEM Agreement with Nonlinear Dynamics.....II-55
Whatman Acquires Schleicher & Schuell.....II-55
GE Healthcare Acquires Amersham Plc.....II-55
GeneProt Extends Collaborative Agreement with Novartis.....II-55 1 $100
GeneProt Collaborates with Lundbeck to Conduct CNS Proteomics Study.....II-56 1 $100
8. Focus on Select Key Players.....II-57 4 $400
Agilent Technologies, Inc. (USA).....II-57
Applied Biosystems (USA).....II-57
Bio-Rad Laboratories, Inc......II-57 1 $100
Dionex Corporation (USA).....II-58
GE Healthcare (United Kingdom).....II-58
Biacore Life Sciences.....II-58
Invitrogen Corporation (USA).....II-58 1 $100
PerkinElmer, Inc. (USA).....II-59
Proteome Systems Ltd. (Australia).....II-59
Shimadzu Biotech (Japan).....II-59 1 $100
Thermo Fisher Scientific (USA).....II-60 1 $100
9. Global Market Perspective.....II-61
Table 2: World Recent Past, Current & Future Analysis for Proteomics by Geographic Region ?US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....II-61 1 $300
Table 3: World Long-term Projections for Proteomics by Geographic Region ?US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....II-62
Table 4: World 10-Year Perspective for Proteomics by Geographic Region/Country ?Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart).....II-62 1 $300
Table 5: World Recent Past, Current & Future Analysis for Proteomics by Product Segment ?Expression Proteomics, Functional Proteomics and Structural Proteomics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....II-63
Table 6: World Long-term Projections for Proteomics by Product Segment ?Expression Proteomics, Functional Proteomics and Structural Proteomics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....II-63 1 $300
Table 7: World 10-Year Perspective for Proteomics by Product Segment ?Percentage Breakdown of Dollar Sales for Expression Proteomics, Functional Proteomics and Structural Proteomics Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart).....II-64 1 $300
10. Glossary of Terms.....II-65 2 $200
1-D, 2-D, 3-D.....II-65
Atmospheric Pressure Ionisation.....II-65
Electrophoresis.....II-65
Functional Genomics.....II-65
High-Throughput.....II-65
Liquid Chromatography (LC).....II-65
Mass Spectrometry (MS).....II-65
Matrix-Assisted Laser Desorption Ionisation (MALDI).....II-65 1 $100
Nuclear Magnetic Resonance.....II-66
X-ray Diffraction.....II-66
Yeast Two-Hybrid System.....II-66
2D-PAGE (Two-dimensional PolyAcrylamide Gel Electrophoresis).....II-66
TOF (Time of Flight).....II-66
Quadrupole.....II-66
Q-TOF (Quadrupole Time of Flight).....II-66
ESI (Electrospray Ionisation).....II-66 1 $100
III. MARKET 55 $1950
1. The United States.....III-1 28 $1375
A. Market Analysis.....III-1
Proteomics Sample Preparation Market.....III-1 1 $75
Table 8: US Proteomics Market (2004): Market Share of Leading Players in Proteomics Sample Preparation Markets -GE Healthcare, Agilent Technologies,, Millipore Corporation, Bio-Rad Laboratories, Inc., Invitrogen Corp., Sigma-Aldrich Co and Others (Ranked by Breakdown of Revenues) (Includes corresponding Graph/Chart).....III-2
Proteomics Arrays Markets.....III-2
Table 9: US Proteomics Market (2005): Market Share of Leading Players in Proteomics Array Segment- Bio-Rad Laboratories, Invitrogen Corporation, and Others (Includes corresponding Graph/Chart).....III-2
Product Launches/Developments.....III-2 11 $975
Strategic Corporate Developments.....III-13 8 $475
Focus on Select Players.....III-21
ActivX Biosciences, Inc......III-21 1 $75
Adnexus.....III-22
Agilent Technologies Inc......III-22
Applied Biosystems.....III-22 1 $75
Bio-Rad Laboratories, Inc......III-23
Bruker Daltonics, Inc......III-23
Caliper Life Sciences.....III-23 1 $75
Digilab Genomic Solutions, Inc......III-24
Dionex Corporation.....III-24
Human Genome Sciences, Inc......III-24 1 $75
Invitrogen Corporation.....III-25
Millipore Corp......III-25
PerkinElmer, Inc......III-25 1 $75
Thermo Fisher Scientific.....III-26
Waters Corp......III-26
Xencor,Inc......III-26 1 $75
Zyomyx, Inc......III-27
B. Market Analytics.....III-27
Table 10: US Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-27 1 $150
Table 11: US Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-28 1 $150
2. Canada.....III-29 3 $225
A. Market Analysis.....III-29
Research Funding.....III-29
Product Launches.....III-29 1 $75
Strategic Corporate Developments.....III-30
Key Player.....III-30
Caprion Proteomics, Inc......III-30 1 $75
B. Market Analytics.....III-31
Table 12: Canadian Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-31
Table 13: Canadian Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-31 1 $150
3. Japan.....III-32 3 $225
A. Market Analysis.....III-32
Strategic Corporate Developments.....III-32 1 $75
Shimadzu Biotech ?A Key Player.....III-33 1 $75
B. Market Analytics.....III-34
Table 14: Japanese Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-34
Table 15: JapaneseLong-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-34 1 $150
4. Europe.....III-35 3 $325
A. Market Analysis.....III-35
Europe on the Fast Track.....III-35
Table 16: European Proteomics Market (2007): Percentage Breakdown of Deployment of Proteomics Technologies in End-Use Segment- Research and Academia Institutions, Pharmaceutical Companies and Clinical Laboratories (Includes corresponding Graph/Chart).....III-35 1 $150
B. Market Analytics.....III-36
Table 17: European Recent Past, Current & Future Analysis for Proteomics by Geographic Region/Country- France, Germany, UK and Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-36
Table 18: European Long-term Projections for Proteomics by Geographic Region/Country- France, Germany, UK and Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-36 1 $150
Table 19: European 10-Year Perspective for Proteomics by Geographic Region/Country ?Percentage Breakdown of Dollar Sales for France, Germany, UK and Rest of Europe Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart).....III-37 1 $150
4a. France.....III-38 2 $150
A. Market Analysis.....III-38
Key Player Review.....III-38
Hybrigenics SA.....III-38 1 $75
B. Market Analytics.....III-39
Table 20: French Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-39
Table 21: French Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-39 1 $150
4b. Germany.....III-40 4 $325
A. Market Analysis.....III-40
Outlook.....III-40
Strategic Corporate Developments.....III-40 2 $150
B. Market Analytics.....III-42
Table 22: German Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million fo Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-42 1 $150
Table 23: German Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-43 1 $150
4c. The United Kingdom.....III-44 5 $350
A. Market Analysis.....III-44
Current Trends in the UK Market for Proteomics.....III-44
Highlights.....III-44
Product Launches.....III-44 1 $75
Strategic Corporate Developments.....III-45 2 $150
B. Market Analytics.....III-47
Table 24: United Kingdom Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million fo Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-47 1 $150
Table 25: United Kingdom Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-48 1 $150
4d. Rest of Europe.....III-49 4 $225
A. Market Analysis.....III-49
Switzerland.....III-49
Portugal.....III-49
Strategic Corporate Developments.....III-49 2 $150
Key Players.....III-51
Biacore Life Sciences.....III-51
Geneva Bioinformatics S.A. (Switzerland).....III-51 1 $75
B. Market Analytics.....III-52
Table 26: Rest of Europe Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-52
Table 27: Rest of Europe Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart).....III-52 1 $150
5. Rest of World.....III-53 3 $300
A. Market Analysis.....III-53
Outlook.....III-53
Australia.....III-53
India .....III-53
Indian Scientific Research towards Functional Genomics and Proteomics .....III-53 1 $75
Strategic Corporate Developments.....III-54
Key Player.....III-54
Proteome Systems Ltd. (Australia).....III-54 1 $75
B. Market Analytics.....III-55
Table 28: Rest of World Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart).....III-55
Table 29: Rest of World Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart) .....III-55 1 $150
IV. COMPETITIVE LANDSCAPE 543 $995
Total Companies Profiled: 170 (including Divisions/Subsidiaries - 182)
--------------------------------------------------------------------------------Region/Country Players
--------------------------------------------------------------------------------
The United States 101
Canada 10
Japan 6
Europe 60
France 5
Germany 17
The United Kingdom 19
Rest of Europe 19
Asia-Pacific (Excluding Japan) 3
Middle East 2