发布时间：2008.9

摘要

INTRODUCTION

Biology is following a path that is reminiscent of the early electronics industry: a miniaturization and large-scale integration process that will revolutionize life science research, drug discovery and development, medical diagnostics and biotechnology. The ongoing miniaturization and large-scale integration process is encompassed in devices known as biochips, including microarrays and lab-on-a-chip microfluidic devices. Biochips represent a diverse group of nanotechnologies that can be expected to exert a significant impact in life science research, diagnostics and medicine.

DNA microarrays are already an established technology generating substantial revenue derived from gene expression, SNP analysis and gene resequencing. The first DNA microarray has recently been approved by the FDA for in-vitro diagnostic applications, and significant market growth can be expected in this application area. Protein microarrays are gaining prominence in the marketplace, while future, emerging array technologies including tissue/cell and glycomics arrays are increasing in importance. Lab-on-chip devices are also making rapid progress in important pharmaceutical and diagnostics market segments.

SCOPE OF STUDY

This report contains:

• Descriptions of various biochips including current and potential applications
• The current market status of biochip products, trends and forecasts for growth over the next 5 to 10 years
• Technological issues, including the latest advances
• A discussion of driving forces in the biochip industry on a global basis, including large-scale integration, research initiatives and drug discovery
• An examination of biochip companies and industry alliances.

METHODOLOGY

Based on our analysis, we evaluate the potential applications of biochips in each of the major market segments, and forecast sales revenues for 2008 through 2013.

For research tools and drug discovery and development, the study presents a forecast from 2008 through 2013 for each of the important products and technologies. For diagnostics, the report forecasts from 2008 through 2013 the demand for microarrays and lab-on-a-chip devices by analysis type. Finally, this study forecasts from 2008 through 2013 the market for LOAC devices by end use segment.

目录及图表

• INTRODUCTION
  • STUDY GOALS AND OBJECTIVES
  • REASONS FOR DOING THE STUDY
  • CONTRIBUTION OF THE STUDY AND FOR WHOM
  • SCOPE AND FORMAT
  • METHODOLOGY
  • INFORMATION SOURCES
  • RELATED BCC REPORTS
  • DISCLAIMER
• SUMMARY
  • Summary Table:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2013 ($ MILLIONS)
  • Summary Figure:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2006-2013 ($ MILLIONS)
• OVERVIEW
  • INTRODUCTION
  • Table 1 BIOLOGY DOWNSIZING REVOLUTION
  • Figure 1 EVOLUTION OF BIOCHIPS
    • BIOCHIP TYPES
  • Figure 2 CLASSIFICATION OF BIOCHIPS
  • Table 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES
  • Table 3 BIOCHIP NOMENCLATURE
    • BIOCHIP TECHNOLOGIES COVERED IN THIS REPORT
  • Table 4 SCOPE OF THIS REPORT
    • MARKET POTENTIAL OF BIOCHIPS
  • Table 5 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2013 ($ MILLIONS)
  • Table 6 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)
    • DRIVING FORCES FOR GROWTH IN BIOCHIPS MARKETS
  • Table 7 BIOCHIP MARKET GROWTH DRIVING FORCES
  • Table 7 (CONTINUED)
    • BIOCHIPS: A CONVERGENCE OF DIVERSE TECHNOLOGIES
  • Table 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS
    • LIFE CYCLE STATUS OF BIOCHIP PRODUCTS
  • Table 9 LIFE CYCLE STATUS OF BIOCHIP TYPES
    • COMMERCIAL STATUS OF BIOCHIPS
      • MICROARRAYS
      • LOAC
    • THE BIOCHIP INDUSTRY
  • Table 10 BIOCHIP INDUSTRY KEY COMPETITORS
• MICROARRAY TECHNOLOGIES
  • INTRODUCTION
    • THE NANOSCALE WORLD
  • Table 11 THE NANOSCALE WORLD
  • Table 12 MICROARRAY TYPES
  • Table 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES
    • The Nanoscale World (Continued)
  • DNA MICROARRAY TECHNOLOGIES
    • INTRODUCTION
  • Table 14 DNA MICROARRAY PLATFORM FEATURES
    • Introduction (Continued)
  • Table 15 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS
    • Introduction (Continued)
      • STEPS IN THE DNA MICROARRAY EXPERIMENT
      • DNA MICROARRAY APPLICATIONS
  • Table 16 DNA MICROARRAY APPLICATIONS
    • Gene Expression Profiling
  • Table 17 PROBES FOR GENE EXPRESSION DNA MICROARRAYS
    • Gene Expression Profiling (Continued)
  • Table 18 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING
  • Figure 3 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE
  • Table 19 GENETIC ANALYSIS TECHNOLOGIES COMPARISON
  • Figure 4 COMPETITIVE SPACE FOR GENE
  • Table 20 PLATFORMS FOR HIGH THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSIS
  • Table 21 GENE EXPRESSION PLATFORMS OF TWO LEADING DNA ARRAY MANUFACTURERS
  • Table 22 PROBE SENSITIVITY AND SPECIFICITY
    • SNP Analysis
  • Figure 5 SNP ANALYSIS PLATFORMS
    • Epigenetic Analysis
  • Figure 6 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM
    • Dna Methylation
  • Figure 7 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION
    • Histones
  • Figure 8 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC
    • DNA and Histone Analysis Workflow
  • Figure 9 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS
    • DNA Methylation Microarrays
    • Chip-On-Chip
  • Figure 10 CHIP-ON-CHIP PROCEDURE
  • Table 23 CHIP ASSAYS
  • Table 24 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES
    • Epigenetic Microarrays
  • Figure 11 MICROARRAY FEATURE DENSITY
  • Figure 12 MICROARRAY RESOLUTION
  • Table 25 MICROARRAY GENOME CONTENT
  • Table 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS
    • Cytogenetic Analysis
  • Table 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES
    • Cytogenetic Analysis (Continued)
  • Figure 13 COMPETITIVE SPACE FOR CNV ANALYSIS
    • Cytogenetic Analysis (Continued)
  • Table 28 CGH MICROARRAY PROBE PLATFORMS
  • Table 29 CGH MICROARRAY TRENDS
    • Cytogenetic Analysis (Continued)
• Table 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS
  • miRNA Analysis
    • miRNA Analysis (Continued)
  • Table 31 TECHNICAL CHALLENGES FOR MIRNAS
    • ARRAYS ON BEADS
  • Table 32 ARRAYS ON BEADS
    • CATALOG AND CUSTOM DNA MICROARRAYS
    • SUPPLY OF REAGENTS AND SAMPLE PREPARATION FOR MICROARRAYS
    • TOXICOGENOMICS
    • DNA SEQUENCING
  • Figure 14 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES
  • Table 33 SINGLE MOLECULE SEQUENCING TECHNOLOGY
  • Table 34 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS
  • Figure 15 COMPETITIVE SPACE FOR HIGH THROUGHPUT GENOMIC ANALYSIS
  • Table 35 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT GENERATION DNA SEQUENCING, 2005
  • Table 35 (CONTINUED)
  • Table 36 NEXT GENERATION DNA SEQUENCING COMPANIES
    • RESEQUENCING APPROACHES IN DIAGNOSTICS
    • DNA MICROARRAY MANUFACTURING
  • Figure 16 DNA MICROARRAY MANUFACTURING TECHNOLOGIES
    • DNA Microarray Manufacturing (Continued)
  • Table 37 DNA MICROARRAY PROBE DENSITY TRENDS
    • DNA MICROARRAY TECHNOLOGY TRENDS
    • DNA MICROARRAY TECHNOLOGY CHALLENGES
  • Figure 17 DNA MICROARRAY COST-VOLUME CURVE
    • PROTEIN MICROARRAY TECHNOLOGIES
    • INTRODUCTION
  • Figure 18 IMPORTANCE OF PROTEINS
    • PROTEOMICS WORKFLOW
  • Figure 19 PROTEIN ANALYSIS APPROACHES CONTRASTED
    • PROTEIN MICROARRAY DESIGN FEATURES
  • Table 38 PROTEIN MICROARRAY PLATFORMS
    • PROTEIN MICROARRAY APPLICATIONS AS RESEARCH TOOLS
  • Table 39 PROTEIN MICROARRAYS AS RESEARCH TOOLS
    • Protein Microarray Applications as ? (Continued)
      • PROTEIN MICROARRAY TYPES
  • Table 40 PROTEIN MICROARRAY PRODUCT TYPES
    • Protein Microarray Types (Continued)
    • Protein Microarray Types (Continued)
      • PROTEIN MICROARRAY TECHNOLOGY CHALLENGES
  • Table 41 PROTEIN MICROARRAY TECHNICAL CHALLENGES
    • Protein Microarray Technology Challenges (Continued)
      • PROTEIN MICROARRAY TECHNOLOGY TRENDS
  • Table 42 PROTEIN MICROARRAY TECHNOLOGY TRENDS
    • EMERGING MICROARRAY TECHNOLOGIES
  • Table 43 EMERGING MICROARRAY TECHNOLOGIES
    • GLYCOMICS MICROARRAYS
      • Glycomics Microarrays (Continued)
    • TISSUE MICROARRAYS
      • Tissue Microarrays (Continued)
    • FUNCTIONAL CELL MICROARRAYS
  • Table 44 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS
    • MICROARRAY TECHNOLOGY TRENDS
  • Table 45 MICROARRAY TECHNOLOGY TRENDS
    • MICROARRAY TECHNOLOGY TRENDS (CONTINUED)
• LAB-ON-A-CHIP TECHNOLOGIES
  • INTRODUCTION
  • Table 46 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE
  • Table 47 LOAC SUBSTRATE TECHNOLOGIES
    • LAB-ON-A-CHIP TYPES
  • Table 48 LAB-ON-A-CHIP TYPES
    • IN-VITRO PROTEOMICS
    • ELECTROPHORESIS ON A CHIP
    • STRUCTURAL PROTEOMICS
    • PCR ON A CHIP
    • IMMUNOASSAYS ON A CHIP
      • Immunoassays on a Chip (Continued)
  • Table 49 IMMUNOASSAY-ON-A-CHIP APPLICATIONS
    • LAB-ON-A-CHIP MAJOR APPLICATIONS
  • Table 50 LAB-ON-A-CHIP MARKET SEGMENTS
  • Table 50 (CONTINUED)
  • Table 51 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS
    • LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS
  • Table 52 LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS
  • Table 53 LOAC TECHNOLOGY PLATFORMS
    • LAB-ON-A-CHIP TECHNOLOGY CHALLENGES
  • Table 54 LAB-ON-A-CHIP TECHNOLOGY CHALLENGES
    • LAB-ON-A-CHIP TECHNOLOGY ... (CONTINUED)
• LIST OF TABLES
  • Summary Table:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, THROUGH 2013 ($ MILLIONS)
  • Table 1 BIOLOGY DOWNSIZING REVOLUTION
  • Table 2 COMPARISON OF THE TWO MAJOR BIOCHIP TYPES
  • Table 3 BIOCHIP NOMENCLATURE
  • Table 4 SCOPE OF THIS REPORT
  • Table 5 GLOBAL VALUE OF BIOCHIP MARKET BY END USE, THROUGH 2013 ($ MILLIONS)
  • Table 6 GLOBAL VALUE OF BIOCHIP PRODUCTS BY GEOGRAPHY, THROUGH 2013 ($ MILLIONS)
  • Table 7 BIOCHIP MARKET GROWTH DRIVING FORCES
  • Table 8 MULTIDISCIPLINARY FIELD OF BIOCHIPS
  • Table 9 LIFE CYCLE STATUS OF BIOCHIP TYPES
  • Table 10 BIOCHIP INDUSTRY KEY COMPETITORS
  • Table 11 THE NANOSCALE WORLD
  • Table 12 MICROARRAY TYPES
  • Table 13 COMPARISON OF DNA AND PROTEIN MICROARRAY TECHNOLOGIES
  • Table 14 DNA MICROARRAY PLATFORM FEATURES
  • Table 15 DNA MICROARRAY PLATFORM COMPARISON FOR MAJOR MANUFACTURERS
  • Table 16 DNA MICROARRAY APPLICATIONS
  • Table 17 PROBES FOR GENE EXPRESSION DNA MICROARRAYS
  • Table 18 EXAMPLE APPLICATIONS OF GENE EXPRESSION PROFILING
  • Table 19 GENETIC ANALYSIS TECHNOLOGIES COMPARISON
  • Table 20 PLATFORMS FOR HIGH THROUGHPUT QUANTITATIVE GENE EXPRESSION ANALYSIS
  • Table 21 GENE EXPRESSION PLATFORMS OF TWO LEADING DNA ARRAY MANUFACTURERS
  • Table 22 PROBE SENSITIVITY AND SPECIFICITY
  • Table 23 CHIP ASSAYS
  • Table 24 TECHNOLOGIES FOR MAPPING GENOMIC LOCATION OF CHROMATIN PROTEINS AND ENZYMES
  • Table 25 MICROARRAY GENOME CONTENT
  • Table 26 PLATFORMS FOR HIGH DENSITY OLIGONUCLEOTIDE EPIGENETICS ARRAYS
  • Table 27 COMPARISON OF CHROMOSOMAL CHANGE DETECTION TECHNOLOGIES
  • Table 28 CGH MICROARRAY PROBE PLATFORMS
  • Table 29 CGH MICROARRAY TRENDS
  • Table 30 FUTURE TECHNOLOGY NEEDS FOR CGH MICROARRAYS
  • Table 31 TECHNICAL CHALLENGES FOR MIRNAS
  • Table 32 ARRAYS ON BEADS
  • Table 33 SINGLE MOLECULE SEQUENCING TECHNOLOGY
  • Table 34 COMPARISON OF SELECTED DNA SEQUENCING PLATFORMS
  • Table 35 BIOCHIP CONTENT IN NHGRI GRANTEES FOR NEXT GENERATION DNA SEQUENCING, 2005
  • Table 36 NEXT GENERATION DNA SEQUENCING COMPANIES
  • Table 37 DNA MICROARRAY PROBE DENSITY TRENDS
  • Table 38 PROTEIN MICROARRAY PLATFORMS
  • Table 39 PROTEIN MICROARRAYS AS RESEARCH TOOLS
  • Table 40 PROTEIN MICROARRAY PRODUCT TYPES
  • Table 41 PROTEIN MICROARRAY TECHNICAL CHALLENGES
  • Table 42 PROTEIN MICROARRAY TECHNOLOGY TRENDS
  • Table 43 EMERGING MICROARRAY TECHNOLOGIES
  • Table 44 U.S. GOVERNMENT INITIATIVES PROMOTING EMERGING MICROARRAYS
  • Table 45 MICROARRAY TECHNOLOGY TRENDS
  • Table 46 MICROFLUIDICS PRODUCT LIFE CYCLE STAGE
  • Table 47 LOAC SUBSTRATE TECHNOLOGIES
  • Table 48 LAB-ON-A-CHIP TYPES
  • Table 49 IMMUNOASSAY-ON-A-CHIP APPLICATIONS
  • Table 50 LAB-ON-A-CHIP MARKET SEGMENTS
  • Table 51 MICROFLUIDIC SYSTEMS ADVANTAGES FOR BIOCHEMICAL ANALYSIS
  • Table 52 LAB-ON-A-CHIP KEY TECHNOLOGY TRENDS
  • Table 53 LOAC TECHNOLOGY PLATFORMS
  • Table 54 LAB-ON-A-CHIP TECHNOLOGY CHALLENGES
• LIST OF FIGURES
  • Summary Figure:
  • GLOBAL VALUE OF BIOCHIP PRODUCTS BY TYPE, 2006-2013 ($ MILLIONS)
  • Figure 1 EVOLUTION OF BIOCHIPS
  • Figure 2 CLASSIFICATION OF BIOCHIPS
  • Figure 3 GENETIC ANALYSIS TECHNOLOGY COMPETITIVE SPACE
  • Figure 4 COMPETITIVE SPACE FOR GENE
  • Figure 5 SNP ANALYSIS PLATFORMS
  • Figure 6 EPIGENOMICS WITHIN THE MOLECULAR BIOLOGY PARADIGM
  • Figure 7 EPIGENETIC CHANGES TO DNA AFFECT GENE EXPRESSION
  • Figure 8 HISTONE TAIL REGIONS MODIFIED BY HAT AND HDAC
  • Figure 9 UPSTREAM AND DOWNSTREAM STEPS IN EPIGENETIC ANALYSIS
  • Figure 10 CHIP-ON-CHIP PROCEDURE
  • Figure 11 MICROARRAY FEATURE DENSITY
  • Figure 12 MICROARRAY RESOLUTION
  • Figure 13 COMPETITIVE SPACE FOR CNV ANALYSIS
  • Figure 14 COMPARISON OF SANGER WITH UHTS DNA SEQUENCING TECHNOLOGIES
  • Figure 15 COMPETITIVE SPACE FOR HIGH THROUGHPUT GENOMIC ANALYSIS
  • Figure 16 DNA MICROARRAY MANUFACTURING TECHNOLOGIES
  • Figure 17 DNA MICROARRAY COST-VOLUME CURVE
  • Figure 18 IMPORTANCE OF PROTEINS
  • Figure 19 PROTEIN ANALYSIS APPROACHES CONTRASTED