发布时间：2007.3

摘要

REPORT HIGHLIGHTS
- The total U.S. sales of media, sera, and reagents for biotechnology was $979 million in 2005 and almost $1.1 billion in 2006. At a compound annual growth rate (CAGR) of 8.9%, this market will grow to reach more than $1.6 billion in 2011.

- Sera will grow much more slowly in the market. This particular sector was worth $338.5 million in 2006 and will reach $401 million by 2011, a CAGR of just 3.5%

- Reagents have the greatest potential for growth, worth $382 million in 2006 and growing at a CAGR of 12.8% to reach almost $700 million by 2011.

INTRODUCTION

Our goal in conducting this study is to provide an overview of the media, sera and reagents used in the production of cell cultures. Although this market is rising due to increased usage, the prices of media have decreased over the last few years. The main objective of this report is to determine the market size, market leaders and factors affecting the use of media, sera and reagents used in biotechnology.

The overview of media and sera-and their composition-and the use of reagents in the field of biotechnology is also examined along with sale figures over the 5-year period from 2006 to 2011. Companies selling these products are profiled, and the factors affecting markets for these products, and how those markets are likely to change, are analyzed.

Our key objective is to present a comprehensive analysis of the current market and the future direction of media, sera and reagents used in biotechnology, with an emphasis on newer products.

SCOPE OF STUDY

This report contains:
- An overview and analysis of the major types of media, sera and reagents used in biotechnology
- Global market forecasts for the industry, including current and historical data as well as 5-year market projections to 2011
- Review of the latest trends in technology, the latest important discoveries, and ideas and estimates for the future
- A detailed analysis of important patents within the past several decades
- Company profiles for the major industry players.

METHODOLOGY

A comprehensive literature and patent search was conducted. The literature included technical newsletters and journals, as well as other sources. The data was collected through interviews with various pharmaceutical and biotechnology companies. Data from these first-hand and second-hand sources were compiled and the projections were based on such estimates as the current number of end-users, potential end-users, likely unit prices, rates of consumption and the market trends.

INFORMATION SOURCES

We surveyed many companies to obtain data for this study. Included were manufacturers and the end-users of the drug delivery systems. We gathered the data from these industries, spoke with officials of these industries, consulted newsletters, company and product literature, a host of technical articles, journals, indexes, and abstracts. Exhaustive investigations of databases by key terminology were undertaken. In addition, we compiled data from current financial and trade information and government sources.

目录及图表

INTRODUCTION

STUDY OBJECTIVES

REASONS FOR DOING THIS STUDY

CONTRIBUTIONS TO THE STUDY

SCOPE OF THE STUDY

METHODOLOGY

INFORMATION SOURCES

ANALYST’S CREDENTIALS

RELATED BCC PUBLICATIONS

BCC ONLINE SERVICES

DISCLAIMER

EXECUTIVE SUMMARY

SUMMARY TABLE U.S. SALES OF MEDIA, SERA AND REAGENTS

IN BIOTECHNOLOGY, THROUGH 2011 ($ MILLIONS)

SUMMARY FIGURE U.S. SALES OF MEDIA, SERA AND REAGENTS

IN BIOTECHNOLOGY, 2004-2011 ($ MILLIONS)

OVERVIEW

DEFINITIONS

MAIN TYPES OF CELL CULTURES

PRIMARY CULTURES

CONTINUOUS CULTURES

CULTURE MORPHOLOGY

CELL CULTURE MEDIA

TABLE 1 TYPES OF CULTURE MEDIA AND THEIR USES BASIC CONSTITUENTS OF MEDIA

Inorganic Salts

TABLE 2 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS

Buffering Systems

Energy Source

Amino acids

Vitamins

Proteins and Peptides

Fatty Acids and Lipids

Trace Elements

Antibiotics

Serum

STORAGE OF MEDIA

Different Types of Media

SERUM-FREE MEDIUM

SERUM FREE MEDIUM COMPOSITION/CONSTITUENTS

Basal Medium

Lipids

Buffers

Trace Elements

Mechanical Stabilizers and Adhesion Factors

Use of Supplements in Serum-Free Medium

Calcium, a Serum-Free Medium Supplement

Primary Functions of Calcium in Cell

Culture Systems

TABLE 3 CONCENTRATION OF CALCIUM IONS IN DIFFERENT MEDIA

Pyridoxal and Pyridoxine, a Serum Free-

Medium Supplement

Primary Function of Pyridoxal and

Pyridoxine in Cell Culture Systems

TABLE 4 CONCENTRATION OF VITAMIN B12 IN DIFFERENT MEDIA

L-Glutamine, a Serum-Free Medium

Supplement

Primary Function of Glutamine in Cell

Culture Systems

TABLE 5 CONCENTRATION OF GLUTAMINE IN DIFFERENT MEDIA

Stearic Acid, A Serum-Free Supplement

Primary Function of Stearic Acid in

Cell Culture Systems

Transferrin, a Serum-free Supplement

Primary Functions of Transferrin in

Cell Culture Systems

Zinc, a Serum-free Medium Supplement

Primary Functions of Zinc in Cell

Culture Systems

TABLE 6 CONCENTRATION OF ZINC IN DIFFERENT MEDIA

Insulin, a Serum-free Media Supplement

Thrombin, a Serum-free Supplement

TABLE 7 SERUM CONTAINING MEDIUM VS SERUM FREE MEDIUM

Disadvantage of Using Serum-free Medium

SIGNIFICANT PROTEIN -FREE AND ANIMAL-ORIGIN

FREE PRODUCTS

SERUM

TABLE 8 LIST OF TYPES OF SERA

CONSTITUENTS OF SERUM

Protein and Peptides

Growth Factors

Albumin

Transferrin

Protease Inhibitors

Amino Acids

Carbohydrates

Fatty Acids and Lipids

Inorganic Salts

Vitamins and Minerals

Others

Infectious Agent

TABLE 9 NORMAL RANGE OF CONCENTRATION OF SERUM CONSTITUENTS

SOURCES OF SERUM

Fetal Bovine Serum (FBS)

Calf Serum

Other Animal Sera

POTENTIAL PROBLEMS WITH SERUM

SERUM SELECTION

REAGENTS

BIOLOGICAL RESPONSE MODIFIERS

Growth Factors

Cytokines, Lymphokines and Interleukins

TABLE 10 LIST OF SELECTED GROWTH FACTORS

TABLE 11 LIST OF CYTOKINES

Interlukins

TABLE 12 LIST OF SELECTED INTERLEUKINS

TABLE 13 LIST OF SELECTED LYMPHOKINES AND CYTOKINES

Colony-Stimulating Factors

Interferons

Tumor Necrosis Factor

Chemokines

TABLE 14 LIST OF SELECTED CHEMOKINES

Attachment Factors

TABLE 15 LIST OF SELECTED ATTACHMENT FACTORS

Serum Replacers or Serum Extenders

TABLE 16 SELECTED REAGENTS THAT SUPPLEMENT REDUCED

SERUM OR SERUM-FREE MEDIA

LIPIDS

FACTORS AFFECTING CELL CULTURE

Temperature

pH 31

Carbon Dioxide (CO2)

Humidity

Concentration of the Nutrients

PROBLEMS ARISING DURING CELL CULTURE

ROLE OF CELL CULTURE

USES OF MEDIA AND SERA AND REAGENTS

GROWTH FACTORS

Neurotrophins

Epidermal Growth Factor (EGF)

Fibroblast Growth Factor

Platelet-Derived Growth Factor (PDGF)

Transforming Growth Factor (TGF)

ANTIBODIES

Monoclonal Antibodies

TABLE 17 APPLICATIONS OF MONOCLONAL ANTIBODIES

TABLE 17 (CONTINUED)

Polyclonal Antibody

Nanobodies

STEM CELLS

TABLE 18 DIFFERENCES BETWEEN EMBRYONIC STEM CELLS AND ADULT STEM CELLS

RECOMBINENT PROTEINS

Human Recombinant Proteins

Granulocyte Colony-Stimulating Factor (G-CSF)

Tissue Plasminogen Activator (PLAT Or Tpa)

Interferons (Ifns)

Insulin-Like Growth Factor 1 (IGF-1)

TABLE 19 A LIST OF HUMAN RECOMBINANT PROTEINS

VACCINES

Types of Vaccines

Innovative Vaccines

Innovative Vaccines (Continued)

REGULATORY

FDA REGULATIONS

EMEA REGULATIONS

USDA REGULATIONS

EDQM REGULATIONS

TABLE 20 CERTIFICATE OF SUITABILITY ISSUED BY EDQM FOR

ALBUMINS

ACTION OF USDA AGAINST BSE

NEW DIRECTIVE REGULATIONS REGARDING BSE

PRODUCTS APPROVED BY FDA IN 2004, 2005 AND 2006

TABLE 21 PRODUCTS APPROVED BY FDA, 2004-2006

TABLE 21 (CONTINUED)

TABLE 21 (CONTINUED)

NEW APPROVALS BY EU

NEW APPROVALS BY EU (CONTINUED)

INDUSTRY STRUCTURE

MEDIA

MARKET LEADERS OF MEDIA USED IN BIOTECHNOLOGY

TABLE 22 MAJOR SUPPLIERS OF MEDIA USED IN BIOTECHNOLOGY

TABLE 22 (CONTINUED)

TABLE 22 (CONTINUED)

TABLE 23 ESTIMATED MARKET SHARE IN 2006 FOR SUPPLIERS AND MANUFACTURERS OF MEDIA (%)

FIGURE 1 ESTIMATED MARKET SHARE FOR SUPPLIERS AND MANUFACTURERS OF MEDIA, 2006 (%)

SERA

MARKET LEADERS OF SERA USED IN BIOTECHNOLOGY

TABLE 24 MAJOR SUPPLIERS OF SERA USED IN BIOTECHNOLOGY

TABLE 25 ESTIMATED MARKET SHARE IN 2006 FOR SUPPLIERS AND MANUFACTURERS OF SERA (%)

FIGURE 2 ESTIMATED MARKET SHARE IN 2006 FOR SUPPLIERS AND MANUFACTURERS OF SERA (%)

REAGENTS

MARKET LEADERS OF REAGENTS USED IN BIOTECHNOLOGY

TABLE 26 MAJOR SUPPLIERS OF REAGENTS USED IN BIOTECHNOLOGY

TABLE 26 (CONTINUED)

FACTORS INFLUENCING DEMAND AND USE

INCREASING USE OF SERUM-FREE MEDIA

FDA REGULATIONS

COST

DEVELOPMENT OF SUCCESSFUL SPECIALTY MEDIA

CELL CULTURE PRODUCTS

FACTORS AFFECTING PRODUCTION OF SERUM

QUALITY CONTROL

THE MATERIALS

Media

Supplement

Vessels

CULTURE ENVIRONMENT

Temperature

pH 65

Carbon Dioxide

CELLS

Toxicity

Contamination

ANTIBIOTICS

PRICES

TABLE 27 AVERAGE PRICES OF CLASSICAL MEDIA, THROUGH 2006 ($/L)

FIGURE 3 AVERAGE PRICES OF CLASSICAL MEDIA, 2003 AND 2006 ($/L)

TABLE 28 AVERAGE PRICES OF SERA, THROUGH 2006 ($/L)

FIGURE 4 AVERAGE PRICES OF SERA, 2003 AND 2006 ($/L)

TECHNOLOGY

NEW DEVELOPMENTS

NEW DEVELOPMENTS BY VARIOUS COMPANIES

Sigma-Adrich

TABLE 29 NEW PRODUCTS BY SIGMA-ALDRICH

Millipore Corporation

Perbio Science

Irvine Scientific

TABLE 30 NEW PRODUCTS BY IRVINE SCIENTIFIC

Invitrogen Corporation

TABLE 31 NEW PRODUCTS BY INVITROGEN CORPORATION

Fisher Biosciences Unit, (Hyclone)

TABLE 32 NEW PRODUCTS BY HYCLONE

Athena ES

Roche Applied Sciences

TABLE 33 NEW PRODUCTS BY ROCHE APPLIED SCIENCES

Animal Technologies, Inc.

Cellgro (MEDIATECH)

Cambrex

SAFC

Celliance Corporation

MARKET BY PRODUCT TYPE

MEDIA

TABLE 34 U.S. MARKET FORECAST FOR SALES OF MEDIA (SERUM FREE AND SERUM REQUIRING), THROUGH 2011 ($ MILLIONS)

FIGURE 5 SALES OF MEDIA (SERUM-FREE AND SERUM REQUIRING) IN U.S. ($ MILLIONS)

Liquid and Powder media

TABLE 35 U.S. MARKET FORECAST FOR SALES OF MEDIA (LIQUID AND POWDER), THROUGH 2011 ($ MILLIONS)

FIGURE 6 SALES OF MEDIA (LIQUID AND POWDER) IN U.S. ($

MILLIONS)

Classical and Specialty Media

TABLE 36 U.S. MARKET FORECAST FOR SALES OF MEDIA (CLASSICAL AND SPECIALTY), THROUGH 2011 ($ MILLIONS)

FIGURE 7 SALES OF MEDIA (CLASSICAL AND SPECIALTY) IN U.S.

($ MILLIONS)

SERA

TABLE 37 U.S. MARKET FORECAST FOR SALES OF SERA, THROUGH 2011 ($ MILLIONS)

FIGURE 8 SALES OF SERA IN THE U.S. 2004-2011 ($ MILLIONS)

Bovine Sera

TABLE 38 U.S. MARKET FORECAST FOR BOVINE SERA, THROUGH 2011 ($ MILLIONS)

FIGURE 9 SALES OF BOVINE SERA IN THE U.S., 2004-2011 ($

MILLIONS)

REAGENTS

TABLE 39 U.S. MARKET FORECAST FOR REAGENTS USED IN BIOTECHNOLOGY, THROUGH 2011 ($ MILLIONS)

FIGURE 10 U.S. SALES OF REAGENTS USED IN BIOTECHNOLOGY, 2004-2011 ($ MILLIONS)

TABLE 40 U.S. MARKET FORECAST FOR BIOLOGICAL RESPONSE MODIFIERS, THROUGH 2011 ($ MILLIONS)

FIGURE 11 SALES OF BIOLOGICAL RESPONSE MODIFIERS IN THE U.S., 2004-2011 ($ MILLIONS)

PATENTS

PATENTS BY PRODUCT

TABLE 41 NUMBER OF SIGNIFICANT PATENTS BY YEAR, 2003-2006

FIGURE 12 NUMBER OF PATENTS BY YEAR, 2003-2006

TABLE 42 PRODUCT-RELATED PATENT BREAKDOWN, 2003-2006

FIGURE 13 PRODUCT-RELATED PATENT BREAKDOWN, 2003-2006 (%)

TABLE 43 SIGNIFICANT PATENTS FOR MEDIA IN 2006

TABLE 44 SIGNIFICANT PATENTS FOR SERA IN 2006

TABLE 45 SIGNIFICANT PATENTS FOR REAGENTS IN 2006

TABLE 45 (CONTINUED)

PATENTS BY COMPANY

TABLE 46 PATENTS BY COMPANY, 2003-2006

TABLE 46 (CONTINUED)

TRENDS BY EMPHASIS

TABLE 47 SHARES OF PATENTS ISSUED BY EMPHASIS, 2003-2006

FIGURE 14 SHARES OF PATENTS ISSUED BY EMPHASIS, 2003-2006 (%)

PATENTS BY COUNTRY

TABLE 48 U.S. PATENTS BY COUNTRY AWARDED, 2003-2006

TABLE 49 TRENDS OF PATENTS ISSUED BY COUNTRY, 2003-2006

PATENTS BY ASSIGNEE

TABLE 50 SHARES OF U.S. PATENTS BY ASSIGNEE

FIGURE 15 NUMBER OF U.S. PATENTS BY ASSIGNEE

FIGURE 16 SHARES OF U.S PATENTS BY ASSGINEE (%)

END USERS

RESEARCH SEGMENT

TABLE 51 U.S. EXPENDITURES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2011 ($ MILLIONS)

FIGURE 17 U.S. EXPENDITURE OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, 2004-2011 ($ MILLIONS)

PRODUCTION SEGMENT

TABLE 52 U.S. MARKET FORECAST FOR MEDIA, SERA AND

REAGENTS IN PRODUCTION SEGMENT, THROUGH 2011 ($ MILLIONS)

FIGURE 18 U.S. SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, 2004-2011 ($ MILLIONS)

CONTRACT SEGMENT

TABLE 53 U.S. MARKET FORECAST FOR MEDIA, SERA AND

REAGENTS IN CONTRACT SEGMENT, THROUGH 2011 ($ MILLIONS)

FIGURE 19 U.S. SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, 2004-2011 ($ MILLIONS)

OTHER SEGMENT

TABLE 54 U.S. MARKET FORECAST FOR MEDIA, SERA AND

REAGENTS IN OTHER SEGMENTS, THROUGH 2011 ($ MILLIONS)

FIGURE 20 U.S. SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENTS ($ MILLIONS)

NEW AND IMPROVED USES

INTERNATIONAL ASPECTS

LATIN AMERICA

TABLE 55 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS

IN BIOTECHNOLOGY IN LATIN AMERICA, THROUGH 2011 ($ MILLIONS)

FIGURE 21 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN LATIN AMERICA, ($ MILLIONS)

EUROPE

TABLE 56 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN EUROPE, THROUGH 2011 ($ MILLIONS)

FIGURE 22 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN EUROPE, 2004-2011 ($ MILLIONS)

ASIA

ISRAEL

INDIA

CHINA

JAPAN

TABLE 57 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN ASIA, THROUGH 2011 ($ MILLIONS)

FIGURE 23 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN ASIA, 2004-2011 ($ MILLIONS)

CANADA

TABLE 58 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN CANADA, THROUGH 2011 ($ MILLIONS)

FIGURE 24 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN CANADA, 2004-2011 ($ MILLIONS)

OTHERS

RUSSIA

CZECH REPUBLIC

SOUTH KOREA

TABLE 59 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN OTHER COUNTRIES, THROUGH 2011 ($ MILLIONS)

FIGURE 25 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN OTHER COUNTRIES, THROUGH 2011 ($ MILLIONS)

TABLE 60 GLOBAL MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, THROUGH 2011 ($ MILLIONS)

FIGURE 26 GLOBAL MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2004-2011 ($ MILLIONS)

TABLE 61 GLOBAL MARKET SEGMENT OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2006 (%)

FIGURE 27 WORLWIDE MARKET SEGMENT OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2006 (%)

COMPANY PROFILE

ADVANCED BIOTECHNOLOGIES, INC. (ABI)

AMGEN, INC.

ATLANTA BIOLOGICALS INC

ATHENA ES/BIOLOGICAL RESEARCH FACULTY & FACILITY,

INC. (BRFF)

BECTON DICKINSON CO. (BD)

BIOGEN, IDEC

BIOVAIL CORPORATION

BIORECLAMATION INC.

CAMBREX CORPORATION

CELL APPLICATIONS, INC.

CENTOCOR INC.

GENENTECH, INC.

HYCLONE (A SUBSIDIARY OF THERMO FISHER SCIENTIFIC,

INC.)

IRVINE SCIENTIFIC

INVITROGEN CORPORATION

MEDIATECH, INC.

MEDIMMUNE, INC.

MILLIPORE CORPORATION

PEPROTECH, INC.

PDL BIOPHARMA, INC

QUALITY BIOLOGICAL INC

R&D SYSTEMS INC

ROCHE APPLIED SCIENCE

SIGMA-ALDRICH

UNITED STATES BIOLOGICAL (U.S. BIOLOGICAL)

GLOSSARY

GLOSSARY

LIST OF TABLES

SUMMARY TABLE U.S. SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, THROUGH 2011 ($ MILLIONS)

TABLE 1 TYPES OF CULTURE MEDIA AND THEIR USES

TABLE 2 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS

TABLE 3 CONCENTRATION OF CALCIUM IONS IN DIFFERENT MEDIA

TABLE 4 CONCENTRATION OF VITAMIN B12 IN DIFFERENT MEDIA

TABLE 5 CONCENTRATION OF GLUTAMINE IN DIFFERENT MEDIA

TABLE 6 CONCENTRATION OF ZINC IN DIFFERENT MEDIA

TABLE 7 SERUM CONTAINING MEDIUM VS SERUM FREE MEDIUM

TABLE 8 LIST OF TYPES OF SERA

TABLE 9 NORMAL RANGE OF CONCENTRATION OF SERUM CONSTITUENTS

TABLE 10 LIST OF SELECTED GROWTH FACTORS

TABLE 11 LIST OF CYTOKINES

TABLE 12 LIST OF SELECTED INTERLEUKINS

TABLE 13 LIST OF SELECTED LYMPHOKINES AND CYTOKINES

TABLE 14 LIST OF SELECTED CHEMOKINES

TABLE 15 LIST OF SELECTED ATTACHMENT FACTORS

TABLE 16 SELECTED REAGENTS THAT SUPPLEMENT REDUCED SERUM OR SERUM-FREE MEDIA

TABLE 17 APPLICATIONS OF MONOCLONAL ANTIBODIES

TABLE 18 DIFFERENCES BETWEEN EMBRYONIC STEM CELLS AND ADULT STEM CELLS

TABLE 19 A LIST OF HUMAN RECOMBINANT PROTEINS

TABLE 20 CERTIFICATE OF SUITABILITY ISSUED BY EDQM FOR ALBUMINS

TABLE 21 PRODUCTS APPROVED BY FDA, 2004-2006

TABLE 22 MAJOR SUPPLIERS OF MEDIA USED IN BIOTECHNOLOGY

TABLE 23 ESTIMATED MARKET SHARE IN 2006 FOR SUPPLIERS AND MANUFACTURERS OF MEDIA (%)

TABLE 24 MAJOR SUPPLIERS OF SERA USED IN BIOTECHNOLOGY

TABLE 25 ESTIMATED MARKET SHARE IN 2006 FOR SUPPLIERS AND MANUFACTURERS OF SERA (%)

TABLE 26 MAJOR SUPPLIERS OF REAGENTS USED IN BIOTECHNOLOGY

TABLE 27 AVERAGE PRICES OF CLASSICAL MEDIA, THROUGH 2006 ($/L)

TABLE 28 AVERAGE PRICES OF SERA, THROUGH 2006 ($/L)

TABLE 29 NEW PRODUCTS BY SIGMA-ALDRICH

TABLE 30 NEW PRODUCTS BY IRVINE SCIENTIFIC

TABLE 31 NEW PRODUCTS BY INVITROGEN CORPORATION

TABLE 32 NEW PRODUCTS BY HYCLONE

TABLE 33 NEW PRODUCTS BY ROCHE APPLIED SCIENCES

TABLE 34 U.S. MARKET FORECAST FOR SALES OF MEDIA (SERUM FREE AND SERUM REQUIRING), THROUGH 2011 ($ MILLIONS)

TABLE 35 U.S. MARKET FORECAST FOR SALES OF MEDIA (LIQUID AND POWDER), THROUGH 2011 ($ MILLIONS)

TABLE 36 U.S. MARKET FORECAST FOR SALES OF MEDIA (CLASSICAL AND SPECIALTY), THROUGH 2011 ($ MILLIONS)

TABLE 37 U.S. MARKET FORECAST FOR SALES OF SERA, THROUGH 2011 ($ MILLIONS)

TABLE 38 U.S. MARKET FORECAST FOR BOVINE SERA, THROUGH 2011 ($ MILLIONS)

TABLE 39 U.S. MARKET FORECAST FOR REAGENTS USED IN BIOTECHNOLOGY, THROUGH 2011 ($ MILLIONS)

TABLE 40 U.S. MARKET FORECAST FOR BIOLOGICAL RESPONSE MODIFIERS, THROUGH 2011 ($ MILLIONS)

TABLE 41 NUMBER OF SIGNIFICANT PATENTS BY YEAR, 2003-2006

TABLE 42 PRODUCT-RELATED PATENT BREAKDOWN, 2003-2006

TABLE 43 SIGNIFICANT PATENTS FOR MEDIA IN 2006

TABLE 44 SIGNIFICANT PATENTS FOR SERA IN 2006

TABLE 45 SIGNIFICANT PATENTS FOR REAGENTS IN 2006

TABLE 46 PATENTS BY COMPANY, 2003-2006

TABLE 47 SHARES OF PATENTS ISSUED BY EMPHASIS, 2003-2006

TABLE 48 U.S. PATENTS BY COUNTRY AWARDED, 2003-2006

TABLE 49 TRENDS OF PATENTS ISSUED BY COUNTRY, 2003-2006

TABLE 50 SHARES OF U.S. PATENTS BY ASSIGNEE

TABLE 51 U.S. EXPENDITURES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2011 ($ MILLIONS)

TABLE 52 U.S. MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, THROUGH 2011 ($ MILLIONS)

TABLE 53 U.S. MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, THROUGH 2011 ($ MILLIONS)

TABLE 54 U.S. MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN OTHER SEGMENTS, THROUGH 2011 ($ MILLIONS)

TABLE 55 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN LATIN AMERICA, THROUGH 2011 ($ MILLIONS)

TABLE 56 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN EUROPE, THROUGH 2011 ($ MILLIONS)

TABLE 57 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN ASIA, THROUGH 2011 ($ MILLIONS)

TABLE 58 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN CANADA, THROUGH 2011 ($ MILLIONS)

TABLE 59 MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN OTHER COUNTRIES, THROUGH 2011 ($ MILLIONS)

TABLE 60 GLOBAL MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, THROUGH 2011 ($ MILLIONS)

TABLE 61 GLOBAL MARKET SEGMENT OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2006 (%)

LIST OF FIGURES

SUMMARY FIGURE U.S. SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2004-2011 ($ MILLIONS)

FIGURE 1 ESTIMATED MARKET SHARE FOR SUPPLIERS AND MANUFACTURERS OF MEDIA, 2006 (%)

FIGURE 2 ESTIMATED MARKET SHARE IN 2006 FOR SUPPLIERS AND MANUFACTURERS OF SERA (%)

FIGURE 3 AVERAGE PRICES OF CLASSICAL MEDIA, 2003 AND 2006 ($/L)

FIGURE 4 AVERAGE PRICES OF SERA, 2003 AND 2006 ($/L)

FIGURE 5 SALES OF MEDIA (SERUM-FREE AND SERUM REQUIRING) IN U.S. ($ MILLIONS)

FIGURE 6 SALES OF MEDIA (LIQUID AND POWDER) IN U.S. ($ MILLIONS)

FIGURE 7 SALES OF MEDIA (CLASSICAL AND SPECIALTY) IN U.S. ($ MILLIONS)

FIGURE 8 SALES OF SERA IN THE U.S. 2004-2011 ($ MILLIONS)

FIGURE 9 SALES OF BOVINE SERA IN THE U.S., 2004-2011 ($ MILLIONS)

FIGURE 10 U.S. SALES OF REAGENTS USED IN BIOTECHNOLOGY, 2004-2011 ($ MILLIONS)

FIGURE 11 SALES OF BIOLOGICAL RESPONSE MODIFIERS IN THE U.S., 2004-2011 ($ MILLIONS)

FIGURE 12 NUMBER OF PATENTS BY YEAR, 2003-2006

FIGURE 13 PRODUCT-RELATED PATENT BREAKDOWN, 2003-2006 (%)

FIGURE 14 SHARES OF PATENTS ISSUED BY EMPHASIS, 2003-2006 (%)

FIGURE 15 NUMBER OF U.S. PATENTS BY ASSIGNEE

FIGURE 16 SHARES OF U.S PATENTS BY ASSGINEE (%)

FIGURE 17 U.S. EXPENDITURE OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, 2004-2011 ($ MILLIONS)

FIGURE 18 U.S. SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, 2004-2011 ($ MILLIONS)

FIGURE 19 U.S. SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, 2004-2011 ($ MILLIONS)

FIGURE 20 U.S. SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENTS ($ MILLIONS)

FIGURE 21 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN LATIN AMERICA, ($ MILLIONS)

FIGURE 22 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN EUROPE, 2004-2011 ($ MILLIONS)

FIGURE 23 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN ASIA, 2004-2011 ($ MILLIONS)

FIGURE 24 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN CANADA, 2004-2011 ($ MILLIONS)

FIGURE 25 SALES OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY IN OTHER COUNTRIES, THROUGH 2011 ($ MILLIONS)

FIGURE 26 GLOBAL MARKET FORECAST FOR MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2004-2011 ($ MILLIONS)

FIGURE 27 WORLWIDE MARKET SEGMENT OF MEDIA, SERA AND REAGENTS IN BIOTECHNOLOGY, 2006 (%)